A clinical syndrome characterized by multi-cognitive decline in previously normal individuals is known as?

The correct choice is dementia, which is a clinical syndrome marked by a progressive decline in multiple cognitive domains, impacting areas such as memory, reasoning, language, and the ability to perform everyday activities. Dementia typically affects individuals who were previously functioning normally and involves gradual deterioration, distinguishing it from other cognitive disorders.

Delirium, while also involving cognitive decline, is characterized by an acute and fluctuating disturbance in attention and awareness, often due to physical illness or substance use. Amnesia pertains specifically to memory loss without the broader cognitive declines, and aphasia primarily affects language abilities, usually through damage to areas of the brain responsible for speech. In contrast, dementia encompasses a wider range of cognitive deficits, making it the appropriate answer for the question posed.