What happens to bone quality in Paget's Disease?

In Paget's Disease, the most significant change occurring in the bone is the alteration in bone quality. The process involves increased osteoclastic bone resorption followed by excessive osteoblastic activity leading to the formation of new bone. This newly formed bone tends to be disorganized and architecturally abnormal compared to normal bone. Therefore, option B is the correct response, as it accurately captures the phenomenon where new bone is larger but weaker than the original bone due to its poor structural integrity, increased vascularity, and abnormal architecture.

Bone density can increase as a result of the high turnover and excessive bone formation, but this does not translate to strength; rather, it may lead to deformities and fractures despite the apparent increase in density. While Paget's Disease does affect bone regeneration, the regeneration is not entirely halted or nonexistent, making the notions associated with options A, C, and D less accurate in describing the changes that characterize the condition.